Tarawneh Biomarker Discovery Lab
Our Research
Overview
The Tarawneh Biomarker Discovery Laboratory is dedicated to the identification of novel fluid biomarkers and drug targets for neurological disorders with a focus on AD and other neurodegenerative disorders. We employ bioinformatics and iPSC research for novel biomarker and drug target discovery.
Experience
Our team has experience in the development and validation of immunoassays for
reliable protein, DNA, and RNA biomarker measurements using state-of-the-art PCR,
proximity ligation assays (PLA), and SIMOA technologies. We also utilize human iPSCs to
study AD disease mechanisms and identify new targets for drug development.
Breakthrough Research
- Identifying novel markers of neuronal and synaptic injury in AD and related dementias
- Identifying novel markers of brain endothelial injury in AD and related dementias
- Identifying novel markers for neuronal-glial-endothelial interactions in AD
Current Projects
- Discovery and Validation of Novel Synaptic Markers for
- Neurodegenerative Disorders
MicroRNAs as Biomarkers of Alzheimer Disease and Frontotemporal Dementia - Elucidating the Role of Endothelial Injury in Neuronal and Synaptic Degeneration
- Utilizing human iPSC cell lines for biomarker and drug target discovery in AD and ADRD
Funding
